People

Postdocs

Dr. Kleopatra Rapti

- Directed evolution of AAV vectors in the liver, eye and kidney
- Experimental & bioinfomatic high-throughput screening pipelines

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Dr. Margarita Zayas (07/16-)

- Directed evolution of AAV capsids for muscle and CNS gene therapy
- Combinatorial AAV capsid evolution via DNA shuffling & peptide display

Dr. Ali Ghanem (05/19-)

- Evolution of cell type-specific AAV capsids in the liver
- Tracking of barcoded AAV capsid variants on the single-cell level

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Dr. Joanna Szumska (07/20-)

- Molecular evolution of synthetic AAV capsids in the CNS of primates
- Combinatorial AAV evolution via DNA shuffling and peptide display

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Dr. Olena Maiakovska (11/20-)

- Analysis of AAV next-generation sequencing data (Illumina, PacBio)
- Establishment of user-friendly AAV alignment and analysis tools

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Dr. Teng Wei Koay (03/22-)

- In vivo AAV library screens in major organs
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Dr. Kristian Leite (03/22-)

- In vivo AAV library screens in major organs
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Dr. Deepak K. Gupta (03/23-)

- Analysis of AAV NGS data
- Development of methods and bioinformatics pipelines for NGS data analysis

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Dr. Sergio D. M. Velasquez (07/22-)

- Development of novel gene therapy vectors derived from Bocavirus
- Establishment of stable bocaviral vector producer cell lines

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PhD students

Ning Meng (05/19-)

- Genetic code expansion using AAV vectors
- AAV vector retargeting through combinatorial peptide display

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Felix Bubeck (04/20-)

- Synthetic AAV ITRs for enhanced vector persistence

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Jonas Becker (03/20-)

- Novel in vivo AAV capsid evolution technologies
- AAV-based CRISPR/Cas applications including SARS_CoV-2

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Nico Fischer (10/20-)

- Combinatorial CRISPR/RNAi strategies against HBV/HDV

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Heinz-Georg (Quique) Hildebrand (05/21-)

- AAV engineering for expression of broadly neutralizing antibodies

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Conradin Baumgartl (11/21-)

- Epigenetic studies on the AAV episome

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Jixin Liu (01/22-)

- AAV Rep protein engineering
- AAV screening in the CNS and musculature

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Technicians

Ellen Wiedtke (02/08-)

- All aspects of AAV production for internal and external use

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Chiara Krämer (03/16-)

- Preparation of samples for NGS analyses and various other expertises

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Lena Naber (09/20-)

Technician

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Emma Gerstmann (10/20-)

Technician

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