People Postdocs Dr. Kleopatra Rapti- Directed evolution of AAV vectors in the liver, eye and kidney - Experimental & bioinfomatic high-throughput screening pipelines Contact Dr. Margarita Zayas (07/16-)- Directed evolution of AAV capsids for muscle and CNS gene therapy - Combinatorial AAV capsid evolution via DNA shuffling & peptide display Dr. Ali Ghanem (05/19-)- Evolution of cell type-specific AAV capsids in the liver - Tracking of barcoded AAV capsid variants on the single-cell level Contact Dr. Joanna Szumska (07/20-)- Molecular evolution of synthetic AAV capsids in the CNS of primates - Combinatorial AAV evolution via DNA shuffling and peptide display Contact Dr. Olena Maiakovska (11/20-)- Analysis of AAV next-generation sequencing data (Illumina, PacBio) - Establishment of user-friendly AAV alignment and analysis tools Contact Dr. Teng Wei Koay (03/22-)- In vivo AAV library screens in major organs - Contact PhD students Ning Meng (05/19-)- Genetic code expansion using AAV vectors - AAV vector retargeting through combinatorial peptide displayContact Felix Bubeck (04/20-)- Synthetic AAV ITRs for enhanced vector persistence Contact Jonas Becker (03/20-)- Novel in vivo AAV capsid evolution technologies - AAV-based CRISPR/Cas applications including SARS_CoV-2 Contact Nico Fischer (10/20-)- Combinatorial CRISPR/RNAi strategies against HBV/HDV Contact Heinz-Georg (Quique) Hildebrand (05/21-)- AAV engineering for expression of broadly neutralizing antibodies Contact Conradin Baumgartl (11/21-)- Epigenetic studies on the AAV episome Contact Jixin Liu (01/22-)- AAV Rep protein engineering - AAV screening in the CNS and musculature Contact Technicians Ellen Wiedtke (02/08-)- All aspects of AAV production for internal and external use Contact Chiara Krämer (03/16-)- Preparation of samples for NGS analyses and various other expertises Contact Lena Naber (09/20-)Technician in training ("Azubi") Contact Emma Gerstmann (10/20-)Technician Contact