- Directed evolution of AAV vectors in the liver, eye and kidney
- Experimental & bioinfomatic high-throughput screening pipelines
Contact
- Directed evolution of AAV capsids for muscle and CNS gene therapy
- Combinatorial AAV capsid evolution via DNA shuffling & peptide display
- Evolution of cell type-specific AAV capsids in the liver
- Tracking of barcoded AAV capsid variants on the single-cell level
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- Molecular evolution of synthetic AAV capsids in the CNS of primates
- Combinatorial AAV evolution via DNA shuffling and peptide display
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- Analysis of AAV next-generation sequencing data (Illumina, PacBio)
- Establishment of user-friendly AAV alignment and analysis tools
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- In vivo AAV library screens in major organs
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Contact
- In vivo AAV library screens in major organs
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Contact
- Analysis of AAV NGS data
- Development of methods and bioinformatics pipelines for NGS data analysis
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- Development of novel gene therapy vectors derived from Bocavirus
- Establishment of stable bocaviral vector producer cell lines
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- Genetic code expansion using AAV vectors
- AAV vector retargeting through combinatorial peptide display
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- Synthetic AAV ITRs for enhanced vector persistence
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- Novel in vivo AAV capsid evolution technologies
- AAV-based CRISPR/Cas applications including SARS_CoV-2
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- Combinatorial CRISPR/RNAi strategies against HBV/HDV
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- AAV engineering for expression of broadly neutralizing antibodies
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